No. 4 Clemson (10-1, CFP No. 3) at South Carolina (8-3, CFP No. 24), Saturday, 7:30 p.m. ET (ESPN)

Line: Clemson by 14.

Series record: Clemson leads 69-42-4.

WHAT'S AT STAKE?

Clemson's run at another national title hangs in the balance. A South Carolina victory would crush the Tigers' hopes to reach College Football Playoff for a third straight season. The Gamecocks have lost the past three rivalry games and are desperate to end that streak and turn things back in their direction.

KEY MATCHUP

South Carolina QB Jake Bentley against Clemson's defensive front. Bentley was battered by the Tigers in the 56-7 loss a year ago, getting sacked twice and throwing for just 41 yards before getting benched. The Tigers front four of ends Clelin Ferrell and Austin Bryant and tackles Dexter Lawrence and Christian Wilkins have combined for 20.5 of Clemson's ACC-leading 39 sacks.

PLAYERS TO WATCH

Clemson: RB Travis Etienne has become the Tigers leading rusher and broke Clemson's mark for rushing touchdowns (11) by a freshman held by C.J. Spiller, who had 10 in 2006. Etienne has run for 681 yards this season.

South Carolina: LB Skai Moore tied the Gamecocks career mark with his 14th interception last week against Wofford. He's also looking to lead South Carolina in tackling for a fourth season, something only 14 players have done in the NCAA. Moore has 73 tackles.

FACTS & FIGURES

Series has been one of runs in recent years: Clemson won four straight (2002-2005), South Carolina won five straight (2009-2013) and now the Tigers have won three. ... Clemson coach Dabo Swinney is seeking his 100th career victory with the Tigers. ... South Carolina is trying for its ninth win of the season after winning nine games combined in 2015 and 2016. ... Clemson has reached double-digit wins in seven straight years. ... The 18 wins combined are the most Clemson and South Carolina have had entering the season finale since they entered with 19 in 2012 and 2013.

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