USC QB Caleb Williams has 'significant' hamstring injury

Southern California quarterback Caleb Williams, left, escapes a tackle by Notre Dame defensive lineman Justin Ademilola as a flag is thrown on the play during the second half of an NCAA college football game Saturday, Nov. 26, 2022, in Los Angeles. (AP Photo/Mark J. Terrill)

Southern California quarterback Caleb Williams (13) is tackled by Utah safeties R.J. Hubert (11) and Cole Bishop (8) during the first half of the Pac-12 Conference championship NCAA college football game Friday, Dec. 2, 2022, in Las Vegas. (AP Photo/Steve Marcus)

Southern California quarterback Caleb Williams (13) looks for an open receiver during the first half of the team's Pac-12 Conference championship NCAA college football game against Utah on Friday, Dec. 2, 2022, in Las Vegas. Utah defensive end Gabe Reid (91) is at right. (AP Photo/Steve Marcus)